Tussitot 100ml

Tussitot 100ml, a cough syrup commonly available in Nigeria:

Tussitot Syrup 100ml - Complete Formulation Profile

📌 Therapeutic Class:
Antitussive + Expectorant Combination

✅ Active Ingredients (per 5ml):

• Pholcodine (5mg) - Opioid-derived cough suppressant

• Ephedrine HCl (4mg) - Bronchodilator/decongestant

• Chlorphenamine Maleate (2mg) - 1st-gen antihistamine

• Ammonium Chloride (40mg) - Expectorant

🎯 Primary Clinical Indications:

• Dry, non-productive cough

• Allergic cough

• Bronchitis-associated cough

• Night-time cough suppression

• Mild asthmatic cough

💊 Dosage Guidelines:

• Adults: 10ml (2 teaspoonfuls) 3-4 times daily

• Children 6-12 years: 5ml 3-4 times daily

• Maximum Duration: 5 days continuous use

• Not recommended for children under 6 years

⚖️ Pharmacological Actions:

• Onset: 20-30 minutes (cough suppression)

• Peak effect: 2-3 hours

• Duration: 4-6 hours

• Note: Pholcodine has cumulative effects

⚠️ Critical Contraindications:

• Respiratory depression

• MAOI use (current or within 2 weeks)

• Severe hypertension

• Hyperthyroidism

• Prostatic hypertrophy

🔄 Significant Drug Interactions:

• Potentiates CNS depressants (alcohol, benzodiazepines)

• Increased sympathomimetic effects with stimulants

• Enhanced anticholinergic effects with TCAs

• May affect anesthesia (pholcodine)

📉 Adverse Effects:

• Common: Drowsiness, dry mouth

• Less common: Palpitations, urinary retention

• Rare: Paradoxical excitation in children

🔬 Monitoring Parameters:

• Respiratory rate

• Cough characteristics

• Mental status

• Urinary output in elderly

💡 Patient Counseling Points:

• Avoid alcohol completely

• May impair alertness (caution when driving)

• Not for productive ("wet") coughs

• Maintain good fluid intake

• Contains sugar (~3g/10ml dose)

🛒 Therapeutic Alternatives:

• For pure suppression: Codeine Linctus

• Non-drowsy option: Dextromethorphan syrups

• Children's formula: Piriton Expectorant

📦 Product Specifications:

• 100ml bottle = 10-20 adult doses

• Storage: Below 30°C

• Typical shelf-life: 2 years