Dillinct Syrup 100ml

Dillinct Syrup 100ml, a popular cough suppressant in Nigeria:

Dillinct Syrup 100ml - Complete Formulation Profile

📌 Therapeutic Class:
Antitussive + Antihistamine Combination

✅ Active Ingredients (per 5ml):

• Dextromethorphan HBr (10mg) - Non-opioid cough suppressant

• Diphenhydramine HCl (7mg) - 1st-gen antihistamine

• Phenylephrine HCl (5mg) - Nasal decongestant

🎯 Primary Clinical Indications:

• Dry, non-productive cough

• Allergic cough

• Post-nasal drip cough

• Night-time cough suppression

• Cold-related cough (adults and children 6+)

💊 Dosage Guidelines:

• Adults: 10ml every 6-8 hours (Max 40ml/24hrs)

• Children 6-12 years: 5ml every 6-8 hours (Max 20ml/24hrs)

• Not recommended for children under 6 years

• Best taken at bedtime for nocturnal cough

⚖️ Pharmacological Properties:

• Onset: 15-30 minutes

• Peak effect: 2 hours

• Duration: 4-6 hours

• Half-life: Dextromethorphan 3-6 hours (prolonged in CYP2D6 poor metabolizers)

⚠️ Critical Contraindications:

• MAOI therapy (current or within 2 weeks)

• Severe hypertension

• Asthma/COPD (risk of secretion retention)

• Bladder neck obstruction

• Angle-closure glaucoma

🔄 Significant Drug Interactions:

• ↑ CNS depression with alcohol/sedatives

• ↑ Sympathomimetic effects with stimulants

• Serotonin syndrome risk with SSRIs/SNRIs

• ↑ Anticholinergic effects with TCAs/antipsychotics

📉 Adverse Effects:

• Common: Drowsiness, dry mouth

• Less common: Restlessness, dizziness

• Rare: Urinary retention, hallucinations (overdose)

🔬 Monitoring Parameters:

• Respiratory pattern

• Cough characteristics

• Mental status

• Hydration in elderly

💡 Patient Counseling:

• Avoid alcohol completely

• May impair alertness (caution when driving)

• Not for productive ("wet") coughs

• Maintain adequate hydration

• Contains sucrose (~3g/10ml dose)

🛒 Therapeutic Alternatives:

• Non-sedating: Levodropropizine syrups

• For chesty cough: Carbocisteine syrups

• Pediatric option: Dillinct Dry Syrup

📦 Product Specifications:

• 100ml bottle = 10-20 adult doses

• Storage: Below 30°C

• Shelf-life: Typically 2 years unopened