ISDIN Nutratopic PRO-AMP Emollient Lotion 400ml

 ISDIN Nutratopic PRO-AMP Emollient Lotion (400ml), a dermo-cosmetic medical device for atopic skin management:

🔬 Core Mechanism

Category: Class IIa Medical Device (EU)
Key Innovation: PRO-AMP® Technology

• Stimulates natural antimicrobial peptides (LL-37, hBD-2)

• Repairs filaggrin-deficient skin barrier
  Texture: Fast-absorbing milk

🧪 Bioactive Formula

1. Barrier Repair Complex:

• Ceramide NP (3:1:1 ratio with cholesterol)

• Omega-6 Fatty Acids (Safflower oil)

• N-Palmitoylethanolamide (PEA) - Endocannabinoid modulator

2. Microbiome Support:
✔ Prebiotic (Inulin)
✔ Postbiotic (Lactobacillus ferment)

3. Hydration Matrix:

• Glycerin (15%)

• Sodium PCA

Free From:
✖ Steroids
✖ Parabens
✖ Perfumes

🎯 Clinical Indications

Primary:

• Atopic dermatitis (maintenance phase)

• Ichthyosis vulgaris

• Epidermolytic hyperkeratosis

Secondary:

• Post-COVID xerosis

• EGFR inhibitor-associated rash

• Post-hematopoietic stem cell transplant GVHD

📊 Evidence Profile

💼 Application Protocol

Acute Phase:

• Apply every 3 hours to affected areas

• Use after wet wrap therapy

Maintenance:

• Twice daily full-body application

• Continue 2 weeks post-lesion resolution

Pro Tip: Apply to damp skin after bathing (<3min post-shower)

⚠️ Safety Profile

Cautions:

• Monitor for rare Malassezia overgrowth

• Possible initial tingling on broken skin

• Not for neonates <1mo

CI: Active HSV infection

🆚 Benchmark Comparison

vs. CeraVe Moisturizing Lotion:

• Advantage: PRO-AMP® microbiome modulation

• Disadvantage: Higher cost/ml

vs. Bioderma Atoderm Intensive:

• Advantage: Faster absorption

• Disadvantage: Less occlusive