Dillinct Dry Syrup 100ml

Dillinct Dry Syrup 100ml, a pediatric cough formulation commonly used in Nigeria and other regions:

Dillinct Dry Syrup 100ml - Complete Pediatric Formulation Profile

📌 Therapeutic Classification:
Antitussive + Antihistamine Combination (Pediatric)

✅ Active Ingredients (per 5ml reconstituted):

• Dextromethorphan HBr (7.5mg) - Non-opioid cough suppressant

• Diphenhydramine HCl (7.5mg) - 1st-gen antihistamine

• Phenylephrine HCl (2.5mg) - Nasal decongestant

🎯 Primary Clinical Indications:

• Dry, non-productive cough in children

• Allergic cough

• Post-nasal drip cough

• Night-time cough suppression

• Cold-related cough (6+ years)

💊 Precision Pediatric Dosage:

• Children 6-12 years: 5ml every 6-8 hours (Max 20ml/24hrs)

• Children 2-5 years: 2.5ml every 6-8 hours (Max 10ml/24hrs)

• Not recommended for infants below 2 years

• Administration: Use provided measuring cup

⚖️ Pharmacokinetics:

• Onset: 15-30 minutes

• Peak effect: 2 hours

• Duration: 4-6 hours

• Half-life: Dextromethorphan ~3-6 hours (prolonged in CYP2D6 poor metabolizers)

⚠️ Critical Contraindications:

• Asthma/COPD (risk of secretion retention)

• MAOI therapy (current or within 2 weeks)

• Severe hypertension

• Bladder neck obstruction

• Angle-closure glaucoma

🔄 Significant Interactions:

• ↑ CNS depression with other sedatives

• ↑ Sympathomimetic effects with stimulants

• ↑ Anticholinergic effects with atropine-like drugs

• Serotonin syndrome risk with SSRIs/SNRIs

📉 Adverse Effect Profile:

• Common: Mild drowsiness, dry mouth

• Less common: Restlessness (paradoxical in some children), dizziness

• Rare: Urinary retention, hallucinations (overdose)

🔬 Essential Monitoring:

• Respiratory effort

• Cough pattern changes

• Hydration status

• CNS excitation signs in young children

💡 Key Administration Notes:

• Reconstitution: Add water to fill line (typically 80ml total volume)

• Storage: Refrigerate after reconstitution (discard after 14 days)

• Best given at bedtime for nocturnal cough

• Contains sucrose (caution in diabetes)

🛒 Clinical Alternatives:

• Non-sedating: Levodropropizine syrups

• For chesty cough: Carbocisteine syrups

• Infant formula: Pediatric Simple Linctus