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Actophlem 200ml

R 130.00

 Actophlem 200ml, a popular expectorant cough syrup in Nigeria:

Actophlem 200ml - Complete Drug Profile

📌 Therapeutic Classification:
Expectorant + Bronchodilator Combination

 Active Composition (per 5ml):

  • Diphenhydramine HCl (12.5mg) - Antitussive/Antihistamine

  • Ammonium Chloride (100mg) - Expectorant

  • Sodium Citrate (60mg) - Mucolytic/Alkalizer

  • Menthol (1mg) - Local soothing agent

🎯 Primary Clinical Indications:

  • Productive cough with thick mucus

  • Bronchitis-associated cough

  • Post-nasal drip cough

  • Mild allergic cough

  • Whooping cough symptom management

💊 Precise Dosage Regimen:

  • Adults: 10ml (2 teaspoonfuls) every 6-8 hours

  • Children 6-12 years: 5ml every 6-8 hours

  • Maximum Daily Dose:

    • Adults: 40ml/24hrs

    • Children: 20ml/24hrs

  • Administration Note: Best taken with warm liquids

⚖️ Pharmacokinetics:

  • Onset: 15-30 minutes (expectorant effect)

  • Peak: 1-2 hours

  • Duration: 4-6 hours

⚠️ Critical Contraindications:

  • Asthma attacks (can thicken secretions)

  • Severe respiratory depression

  • Concurrent MAOI therapy

  • Neonates/infants (<2 years)

  • Porphyria patients

🔄 Significant Interactions:

  • Potentiates CNS depressants (alcohol, opioids)

  • Anticholinergic synergy (with TCAs, antipsychotics)

  • Reduced efficacy with urinary acidifiers

  • Increased sedation with benzodiazepines

📉 Adverse Effect Profile:

  • Common: Drowsiness, dry mouth, mild GI upset

  • Less frequent: Urinary retention, blurred vision

  • Rare: Paradoxical excitation (in children)

🔬 Therapeutic Monitoring:

  • Respiratory secretion consistency

  • Cough pattern changes

  • Sedation levels

  • Urinary function in elderly

💡 Essential Patient Counseling:

  • Maintain adequate hydration

  • Avoid driving/operating machinery

  • Not for persistent dry cough

  • Shake well before each use

  • Sugar content: ~3.2g per 10ml dose

🛒 Therapeutic Alternatives:

  • For pure expectoration: Bisolvon Syrup

  • Non-sedating option: Carbocisteine

  • Children's formula: Benylin Expectorant

📦 Packaging Economics:

  • 200ml bottle = 20 adult doses

  • Average duration: 5 days at standard dosing