Acurate 40s

 Acurate 40s, a commonly used analgesic/antipyretic medication:

Acurate 40s (Paracetamol) - Complete Drug Profile

📌 Therapeutic Class:
Non-opioid analgesic/antipyretic

✅ Active Ingredient:

• Paracetamol (Acetaminophen) 500mg per tablet

🎯 Primary Clinical Indications:
✔️ Mild to moderate pain (headache, dental pain, musculoskeletal pain)
✔️ Fever reduction
✔️ Post-vaccination pyrexia in children
✔️ Osteoarthritis pain (in combination therapies)

💊 Dosage Guidelines:

• Adults & Children >12yrs:

  • 1-2 tablets every 4-6 hours

  • Maximum: 8 tablets (4g) in 24 hours

• Children 6-12yrs:

  • ½-1 tablet every 4-6 hours

  • Maximum: 4 tablets in 24 hours

• Take with water, with or without food

⚖️ Pharmacokinetics:

• Onset: 30 minutes

• Peak effect: 1-2 hours

• Duration: 4-6 hours

• Half-life: 2-3 hours (prolonged in liver impairment)

⚠️ Critical Contraindications:
❌ Severe hepatic impairment
❌ Known hypersensitivity to paracetamol
❌ Chronic alcoholism
❌ G6PD deficiency (caution)

🔄 Key Drug Interactions:

• Warfarin: ↑ INR (with chronic high doses)

• Alcohol: ↑ Hepatotoxicity risk

• Isoniazid: ↑ Liver damage potential

• Cholestyramine: ↓ Absorption

📉 Adverse Effects:

• Rare at therapeutic doses:

  • Skin rashes

  • Blood dyscrasias

• Overdose (>10g):

  • Hepatotoxicity (peak at 72-96 hours)

  • Possible renal failure

💡 Patient Counseling:
✔️ Do not exceed recommended dose
✔️ Avoid concurrent alcohol use
✔️ Check other medications for paracetamol content
✔️ Seek immediate help if overdose suspected
✔️ Not for chronic pain management without medical advice

🛒 Therapeutic Alternatives:

• NSAIDs (for inflammatory pain)

• Aspirin (for antiplatelet effects)

• Combination products (with caffeine/codeine)

📦 Pack Specifications:

• 40 tablets per pack

• Storage: Below 30°C, protect from moisture

• Shelf-life: Typically 3 years

• Price Range: Affordable OTC medication

Clinical Pearls:

1. First-line for mild pain/fever in pregnancy (Category A)

2. Safer GI profile vs NSAIDs

3. No anti-inflammatory effects

4. Consider weight-based dosing in pediatric patients

Regulatory Status:

• OTC in most countries

• Some combination products may be prescription-only

Overdose Management:

• N-acetylcysteine is antidote

• Most effective when given within 8-10 hours post-ingestion

Always check for concurrent paracetamol content in other medications to avoid unintentional overdo